Using our understanding of how light interacts with tissues and by administering targeted fluorescent probes, we can image important molecular changes in disease in both mice and humans.

We have developed multiple series of near infrared fluorescence based optical imaging probes to target disease. Combining optical molecular imaging agents with minimally invasive catheters and endoscopes we have developed, has allowed us to clinically translate optical imaging to humans. Optical imaging probes we have published on include those targeting specific enzyme overexpression, immune cell upregulation, cell surface receptors, extracellular matrix components, and metabolic changes.