Using our understanding of how light interacts with tissues and by administering targeted fluorescent probes, we can image important molecular changes in disease in both mice and humans. We have developed multiple series of near infrared fluorescence based optical imaging probes to target disease. Combining optical molecular imaging agents with minimally invasive catheters and endoscopes we have developed, has allowed us to clinically translate optical imaging to humans. Optical imaging probes we have published on include those targeting specific enzyme overexpression, immune cell upregulation, cell surface receptors, extracellular matrix components, and metabolic changes.

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  • Schematic and photograph of dual channel clinical fluorescence endoscope

 

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  • Surface reflectance and (d) endoscope-based NIR fluorescence images acquired 3 hours after injection of ICG by using the handheld OMI system demonstrate substantially elevated ICG uptake within the intrahepatic colorectal tumor relative to the adjacent hepatic parenchyma, allowing for ready differentiation between normal and malignant tissue. WL = white light