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Many human diseases can be best modeled in mice. Transgenic murine models provide a route to understand the effects of single and multiple genetic changes.

Mouse models of human cancers, cardiovascular disease, autoimmune disease, and neurodegeneration allow an integration of effects that cannot be adequately modeled in cell culture. We work closely with top researchers around the country who have developed the defining murine models of specific disease syndromes and classic murine models used to study specific gene mutations. These close collaborations allow us to more rapidly develop and test imaging probes, devices, and algorithms to translate our methods into improved human molecular imaging.