All living cells need energy and building blocks such as sugars, lipids, nucleic acids, and amino acids. With disease and with response to treatment, metabolism often precedes anatomic alterations.
Cell signaling receptors are vital in communicating information about the environment to cells. We image intracellular and cell surface signaling receptors important in disease.
Tumors are composed of more than just tumor cells. The tumor microenvironment is made up of cancer cells, blood vessels, stromal cells, immune cells, and extracellular matrix.
Many human diseases can be best modeled in mice. Transgenic murine models provide a route to understand the effects of single and multiple genetic changes.
Using our understanding of how light interacts with tissues and by administering targeted fluorescent probes, we can image important molecular changes in disease in both mice and humans.
Translating the best science to improve human health is at our core. We focus both on trials that help define the role of specific molecular imaging agents, and trials using imaging to improve and optimize novel therapeutics.